SIMULATION RELIABILITY OF PHYSIOLOGICAL PHENOMENA BY CARDIAC ACTION POTENTIAL MODEL

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia mechanisms, are usually performed with channels expressed in non myocytes, or with non-human myocytes. Differences between cell types and species affect results. Thus, an accurate model for the undiseased human ventricular action potential (AP) which reproduces a broad range of physiological behaviors is need...

A Map-Based Model of the Cardiac Action Potential

The heart cells that are directly involved in the dynamics of its electrical activity include pacemaker and nonpacemaker cells. The peacemaker cells generate spontaneous action potentials and are characterized by a slow rate of the depolarization. These cells are found in sinoatrial and atrioventricular nodes of the heart and initiate the propagation of electrical activity throughout the heart....

A Dynamic Model of the Cardiac Ventricular Action Potential

The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2"]j, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca'+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both the Na+-Ca'+ exchanger (INaCa) and a nonspecific Ca'+-activated current (Ins(...

Simulation of Cardiac Action Potentials Background Information

The goal of assignments related to this document is to experiment with a numerical simulation of the cardiac action potential. The form of this simulation is just as described in class, using the Hodgkin-Huxley formalism and differential equations to reproduce the currents responsible for the action potential. To simulate the cardiac action potential, it is necessary to expand the number of cha...

Cardiac Action Potential Prolongation Induced by Isolated Thioridazine Enantiomers